Contact Information
University of Illinois
215 RAL, Box C-3
600 S. Mathews Avenue
Urbana, IL 61801
Research Areas
Additional Campus Affiliations
Steven L. Miller Chair, Chemical and Biomolecular Engineering
Professor, Chemical and Biomolecular Engineering
Professor, Bioengineering
Professor, Biomedical and Translational Sciences
Professor, Carl R. Woese Institute for Genomic Biology
Biography
Dr. Huimin Zhao is the Steven L. Miller Chair Professor of chemical and biomolecular engineering, and professor of chemistry, biochemistry, biophysics, and bioengineering at the University of Illinois at Urbana-Champaign (UIUC). He received his B.S. degree in Biology from the University of Science and Technology of China in 1992 and his Ph.D. degree in Chemistry from the California Institute of Technology in 1998 under the guidance of Nobel Laureate Dr. Frances Arnold. Prior to joining UIUC in 2000, he was a project leader at the Industrial Biotechnology Laboratory of the Dow Chemical Company. He was promoted to full professor in 2008. Dr. Zhao has authored and co-authored over 430 research articles and over 30 issued and pending patent applications. In addition, he has given over 490 plenary, keynote, or invited lectures. Thirty-seven (37) of his former graduate students and postdocs became professors or principal investigators around the world. Dr. Zhao received numerous research and teaching awards and honors such as AIChE Daniel I.C. Wang Award, AIChE FP&B Division Award, ECI Enzyme Engineering Award, ACS Marvin Johnson Award, and SIMB Charles Thom Award. His primary research interests are in the development and applications of synthetic biology, machine learning, and laboratory automation tools to address society’s most daunting challenges in health, energy, and sustainability.
Research Interests
Synthetic biology; AI/ML; automation; natural product biosynthesis; protein engineering; metabolic engineering; genome engineering; directed evolution
Research Description
Zhao group develops and applies synthetic biology, machine learning, and laboratory automation tools to engineer functionally improved or novel proteins, pathways, and genomes for biotechnological and biomedical applications. In parallel, Zhao group investigates the protein structure-function relationship, cell metabolism, and mechanisms of gene expression and regulation. The current research program in Zhao grouo centers on four distinct yet related areas, including foundational tool development, drug discovery and development, industrial biotechnology, and mammalian synthetic biology.
Recent Publications
Asserghine, A., Baby, A., Gao, E., Zhao, H., & Rodríguez-López, J. (2024). Inducing and real-time monitoring of lead (de)sulfation processes using scanning electrochemical microscopy for applications in the refurbishment of lead-acid batteries. Electrochimica Acta, 475, Article 143620. https://doi.org/10.1016/j.electacta.2023.143620
Boob, A. G., Zhu, Z., Intasian, P., Jain, M., Petrov, VA., Lane, S. T., Tan, S.-I., Xun, G., & Zhao, H. (2024). CRISPR-COPIES: an in silico platform for discovery of neutral integration sites for CRISPR/Cas-facilitated gene integration. Nucleic acids research, 52(6), Article gkae062. https://doi.org/10.1093/nar/gkae062
Boob, A. G., Chen, J., & Zhao, H. (2024). Enabling pathway design by multiplex experimentation and machine learning. Metabolic Engineering, 81, 70-87. https://doi.org/10.1016/j.ymben.2023.11.006
Burke, M. D., Denmark, S. E., Diao, Y., Han, J., Switzky, R., & Zhao, H. (2024). Molecule Maker Lab Institute: Accelerating, advancing, and democratizing molecular innovation. AI Magazine, 45(1), 117-123. https://doi.org/10.1002/aaai.12154
Dong, G., Zhao, Y., Ding, W., Xu, S., Zhang, Q., Zhao, H., & Shi, S. (2024). Metabolic engineering of Saccharomyces cerevisiae for de novo production of odd-numbered medium-chain fatty acids. Metabolic Engineering, 82, 100-109. https://doi.org/10.1016/j.ymben.2024.01.009